asperulosidic acid
Asperulosidic acid
CAS: 25368-11-0
Molecular Formula: C18H24O12
asperulosidic acid - Names and Identifiers
asperulosidic acid - Physico-chemical Properties
| Molecular Formula | C18H24O12 |
| Molar Mass | 432.38 |
| Density | 1?+-.0.1 g/cm3(Predicted) |
| Boling Point | 715.6±60.0 °C(Predicted) |
| Solubility | DMSO, Pyridine, Methanol, Ethanol, etc. |
| Appearance | White crystal or powder |
| pKa | 4.32±0.70(Predicted) |
| Storage Condition | -20°C |
| Sensitive | Easily absorbing moisture |
asperulosidic acid - Risk and Safety
| WGK Germany | 3 |
asperulosidic acid - Reference
| Reference Show more | 1. He, Mingzhen, et al. "Application of characteristic ion filtering with ultra-high performance liquid chromatography quadrupole time of flight tandem mass spectrometry for rapid detection and identification of chemical profiling in Eucommia ulmoides Oliv." 2. He, Jingyu, et al. "Asperuloside and asperulosidic acid exert an anti-inflammatory effect via suppression of the NF-κB and MAPK signaling pathways in LPS-induced RAW 264.7 macrophages." International journal of molecular sciences 19.7 (2018): 2027.https:// 3. [IF=4.759] Mingzhen He et al."Application of characteristic ion filtering with ultra-high performance liquid chromatography quadrupole time of flight tandem mass spectrometry for rapid detection and identification of chemical profiling in Eucommia ulmoides Oliv."J C 4. [IF=4.183] Jingyu He et al."Asperuloside and Asperulosidic Acid Exert an Anti-Inflammatory Effect via Suppression of the NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages."Int J Mol Sci. 2018 Jul;19(7):2027 5. [IF=5.34] Wei Zou et al."Imperatae rhizoma-Hedyotis diffusa Willd. herbal pair alleviates nephrotic syndrome by integrating anti-inflammatory and hypolipidaemic effects."Phytomedicine. 2021 Sep;90:153644 6. [IF=3.205] Jia Jia et al."Screening of anti-complement active ingredients from Eucommia ulmoides Oliv. branches and their metabolism in vivo based on UHPLC-Q-TOF/MS/MS."J Chromatogr B. 2019 Aug;1124:26 7. [IF=2.419] Zhiyong Zhang et al."An integration of UPLC-Q-TOF/MS and chemometrics analysis for the holistic quality evaluation of different geographical Paederia scandens."RAPID COMMUNICATIONS IN MASS SPECTROMETRY. 2022 Jul;36(13):e9317 |
asperulosidic acid - Reference Information
| function | plantaric acid is a iridoid substance, which is an important active ingredient in Noni juice, anti-virus, anti-oxidation, anti-distortion and other activities are closely related to human health. |
| preparation | Take 10kg hedyotis diffusa to add 10 times the volume concentration of 75% ethanol reflux extraction 2 times, 1h each time, concentrated under reduced pressure at 60 ℃ to a relative density of 1.10-1.20; Decolorized by adding 0.5% by weight active carbon to the concentrated solution, centrifuged at high speed, the supernatant was taken and dried under vacuum to obtain crude extract of hedyotis diffusa; the crude extract was dissolved in 30% methanol, eluted with a 30% methanol aqueous solution using an ODS open column as a stationary phase, and methanol was recovered and dried under vacuum. After drying, the sample was dissolved in 5% methanol and separated by high-speed countercurrent chromatography to obtain Trifolium glucuronide. Preparation conditions: YMC-PackODS-A column (20 ×, 5 μm) as the column, with the volume concentration of methanol as the mobile phase, gradient elution 60min; Detection wavelength 235nm; the injection volume was 100 μL. |
| biological activity | Asperulosidic Acid (ASPA) is a kind of iridoid glycoside with biological activity, extracted from the herb Hedyotis diffusa Willd. Asperulosidic Acid (ASPA) has antitumor, antioxidant and anti-inflammatory effects. Asperulosidic Acid (ASPA) plays an anti-inflammatory role by inhibiting the release of inflammatory cytokines (TNF-α,IL-6) through inhibiting NF-κB and mitogen activated protein kinase (MAPK) signaling pathways. |
| Cell Line: | RAW 264.7 cells RAW 264.7 cells |
| Concentration: | 40 μg/mL, 80 μg/mL, and 160 μg/mL 40 μg/mL, 80 μg/mL, and 160 μg/mL |
| Incubation Time: | Pre-treatment 1 hour Pre-treatment 1 hour |
| Result: | Decreased TNF-α and IL-6 mRNA expression. Decreased IκB-α phosphorylation and Erk1/2 phosphorylation. |
Last Update：2024-04-09 20:52:54
Supplier List
Spot supply
Product Name: Asperulosidic acid Visit Supplier Webpage Request for quotationCAS: 25368-11-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Asperulosidic acid Visit Supplier Webpage Request for quotationCAS: 25368-11-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History